Re: What about nuclear DNA mutation rates? #3 (was for SJones, part 2)

From: Huxter4441@aol.com
Date: Mon Oct 30 2000 - 18:04:44 EST

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    In a message dated 10/29/2000 5:36:09 PM Eastern Standard Time,
    sejones@iinet.net.au writes:

    << Reflectorites
     
     I am trying to wind down my posts on the Reflector. So these two posts on
    this topic will be my last unless Huxter can come up with something new.

    =================================
    So sorry to be wasting your time.
    ==================================
     
     On Mon, 23 Oct 2000 07:39:20 EDT, Huxter4441@aol.com wrote:
     
    >SJ>But if the "nuclear DNA molecular clock dates" disagrees with the mtDNA
    >dates, then someone has a problem!
     
     HX>LOL?
      HX>Ahhh - I should have read down a bit farther! WHY? No cop-outs this
    >time
     
     I never use (or even need) "cop-outs".

    ===================================
    If you say so.
    ===================================
     
     And I have already answered this question in Part 1.
     
     HX>- YOU made a claim, let's hear your rationale. Supported by evidence,
    >of course
     
     See Part 1. Huxter seems to be repeating himself.
     
    =================================
    Yes - I am repeatedly trying ot get you to supply a rationale for your belief
    regarding your lack of 'surprise' (re: congruence of molecular/fossil dates).
    =================================

    >>HX>Do we just ignore that much larger amount of information
     
    >SJ>See above. It was the above scientific journals who Huxter is claiming
    is
    >>"ignore that much larger amount of information". I just posted what New
    >>Scientist said.
     
     HX>And I asked YOU a question, not the authors of the article.
     
     And I have *answered* Huxter's "question"!

    ==============================
    You did? All I saw was that you didn't know what I meant that there is more
    information ion the nuclear genome than in the mt genome. THAT was your
    answer?
    ==============================
     
     HX>You can keep
    >trying to divorce yourself from what you posted,
     
     I am not "trying to divorce yourself from what" I "posted". I *agree* with
     the article since I posted it!
     
    =================================
    But you have thus far refused to address the technical issues. I understand
    you are a layman, but that is no excuse.
    =================================

     But it is *Huxter* whop seems to have a problem with it, although he
     keeps `dancing around the ring' without coming out and saying what it is.
     If Huxter doesn't disagree with the New Scientist article, then what is his
     point?

    =================================
    I can do without your ridiculous claims about me 'dancing around the ring.'
    My point was - and should have been obvious - that it was YOUR conclusions
    that were unwarranted given that this was a single article of dozens on the
    topic and that nuclear DNA molecular clocks were not even mentioned!
    =================================
     
     HX>but YOU posted it for a reason,
     
     I gave my "reason" in my comments before the article at the time. Here
     they are again:
     
     ==========================================================
     =============
     On Sun, 01 Oct 2000 06:37:35 +0800, Stephen E. Jones wrote:
     
     [...]
     
    >Here is a New Scientist article, based on a SCIENCE report, which says
    >that molecular clocks, the rate of neutral mtDNA mutation, is possibly 100
    >times faster than previously thought.
    >
    >If this turns out to be really the case, it would bring any "Mitochondrial
    >Eve", the last common female genetic ancestor, which has been variously
    >dated from ~ 400-60 kya, into closer contact with Biblical time-frames.
    >
    >I have also attached another New Scientist article from the same issue,
    >which claims that the maximum human life-span might be much longer than the
    >current estimate of around 120 years.
    >
    >If this holds up, it could not be ruled out that the ages of the
    antediluvians
    >in Genesis 5 (e.g. "Methuselah lived 969 years" -Gn 5:27); were literally
    >true.
    >
    >I would imagine that Hugh Ross and the ICR will *love* these!
    >
    >Whatever happens, this shows that scientific `fact', especially in the
    field of
    >human origins, is only as good as the next discovery.
     
     [...]
     ==========================================================
     =============
     
     HX>iow I am having a hard time seeing WHY you posted it, if you have no
    >intention of defending it or using to support one viewpoint or another.
     
     What is there to "defend"? And I am still trying to find out what *is* the
     other (i.e. Huxter's) "viewpoint" (assuming he has one).

    ===================================
    Yes Steve.... I have no viewpoint. No point either. You clever creationists
    have cornered the market on points. I knew there was a reason that I tended
    not to reply to you.... Sure, you don't use the dreaded swear words, but you
    are nonetheless insulting and snide.
    ====================================
     
     [...]
     
    >HX>I see. I thought maybe you could formulate your own opinion. I didn't
    >>realize that you were simply a 'reporter' for this list, busily scribbling
    >>down and quoting what others have written...
     
     SJ>I am *touched* that Huxter is more interested in my "own opinion" rather
    >than those dumb old scientific journals! :-)
     
     HX>:) Of course, I did not seem to get the same thing you had hoped
    everyone
    >would get from the article. I was under the impression that this is a
    >'discussion' group, not a 'let's post articles and refuse to discuss them'
    >group. If you are unprepared or unwilling to discuss topics YOU bring up,
    >then perhaps you should think twice about posting them.
     
     I am more than happy to "discuss topics" that I "bring up", namely whether
     the last common mtDNA ancestor (Mitochondrial Eve) might be even
     more recent than previously thought. And therefore might be close to, if
     not overlapping, the dates of the antediluvians given in the genealogies in
     the early chapters of Genesis.

    ===================================
    Did these antedeluvians even exist? Mitochondrial Eve, byt he way, is a
    misleading characterization (not necessarily by you) - population studies and
    so one indicate that there was never fewer than several thousand individuals
    in the population that gave rise to humanity.
    Of course, if the mtDNA dates are at odds with nuclear DNA dates, what then?
    Was Eve just a free-floating mitochondrion?
    ===================================

     
     But to date Huxter has made it a discussion of a topic that *he* brought
     up, "What about nuclear DNA mutation rates?" except he has not said
     much about these "nuclear DNA mutation rates" but has wasted a lot of
     time trying to show that my knowledge of this subject is limited (something
     I freely admit).

    =====================================
    It is unfortunate - but not surprising - that you see it that way. YOU
    brought up the topic of the molecular clock by posting the article you did.
    My query deals directly with your conclusions regarding that article. The
    waste of time is mine, as I have yet to get you to actually pose a question
    that I might answer or answer any of mine.
    =====================================
     
    >SJ>And anyway, what "larger amount of information" is that exactly?
     
     [...]
     
    >HX>Surely you recognize that the nuclear genome is many orders of magnitude
    >>larger than the mitochondrial genome?
     
    >SJ>Huxter is right on that one.
    >>
    >>But that was not what Huxter said. It does not follow that just because
    "the
    >>nuclear genome is many orders of magnitude larger than the mitochondrial
    >>genome" there will be a "larger amount of information" regarding
    *molecular
    >>clock* studies.
     
     HX>Why not? Since DNA sequence data is what is used in these analyses, why
    >wouldn't there be more of it to use in the nuclear genome?
     
     I had already answered that (see below).

    ===================================
    Unsatisfactorally. Your answer is irrelevant, as I tried to point out.
    ===================================

    >SJ>As I said before, the problem as I understand it, with any part of the
    >>nuclear genome that it is thought to be more likely than the mitochondrial
    >>genome to have been affected by natural selection.
     
     HX>Probably so. Nevertheless, with a larger amount of genetic data
    available,
    >one can assume that such idiosyncrasies will be 'smoothed over.'
     
     Not necessarily. If nuclear DNA can be affected by natural selection then
     it *all* could have been. Therefore `smoothing over' (e.g. by averages)
     could all be affected by selection.

    ======================================
    Of course nuclear DNA is affected by selection! I don't understand your
    last sentence. You stated before that you felt that mtDNA was unaffected by
    selection because mtDNA does not code for 'body parts.' Now you are saying
    that selection may in fact do the same thing to mtDNA that it does to nuclear
    DNA?
    =======================================
     
     HX>As I
    >believe I have mentioned before, protein coding nuclear loci have been used
    >to accurately reconstruct known phylogenies.
     
     I have no problem with that.
     
     HX>Since we do not assume a
    >uniform mutation rate in nuclear DNA molecular clock analyses, it seems to
    me
    >that such issues are irrelevant
     
     My understanding is that they don't necessarily "assume a uniform mutation
     rate in" mitochondrial "DNA molecular clock analyses" either. But because
     mtDNA is thought to be selectively neutral, since it doesn't code for body
     parts, it is a more reliable record of the neutral mutations and their rate.

    =====================================
    Most that I am familiar with do, actually. How can mtDNA be selectively
    neutral? Mitochondrial genes can mutate just like nuclear genes, and if the
    mutation is detrimental, it will be selected against. Whether or not mtDNA
    codes for body parts is irrelevant to its selective neutrality or lack
    thereof. It is thought, as I explained before, that because mtDNA mutates
    faster than nuclear DNA that more phylogenetic information can be gleaned
    from a smaller amount of data and that because it is inherited only from the
    mother (this is disputed) that it offers a 'pure' line of descent. I'm not
    sure where you got the idea that molecular clock calculations were reliant
    upon neutral mutations in the first place. The earliest molecular clock
    studies - using proteins - were done without the knowledge of the neutral
    theory. The mutation rate is the mutation rate, neutral or otherwise. That
    detrimental mutations get purged from the genome by selection is true
    regardless of the source.
    ====================================
     
    >>HX>because if we put a certain spin on reality,
     
    >SJ>I am glad Huxter said "we"! Claims about putting a "spin on reality"
    >>cut both ways.
     
     [...]
     
    >>HX>It is a shame you cut out the context of my quote.
     
     SJ>But of *course* I did - I am a creationist remember! :-)
     
     HX>Yes, I know. And that is why I was not surprised.
     
     See below.
     
    >>HX>I understand creationists
    >>of all stripes have a distinct tendancy to do so such that a statement can
    >>appear to mean something it originally did not.
     
     SJ>See! :-)
    >
    >But seriously, if Huxter thinks I have "cut out the context of" his "quote"
    >he can repost it and say why he thinks I did.
     
     In fact on checking back there was no "quote" by Huxter for me to "cut
     out the context of". Here is Huxter's *entire* post:
    ====================================
    True in the sense that what you responded to was not surrounded by several
    paragraphs of text. But your line-by-line response expunged the spirit of
    the post, which is tantamount to what I said earlier.
    ==================================

    [for brevity]
     ============================================================
     On Sun, 1 Oct 2000 19:26:11 EDT, Huxter4441@aol.com wrote:
     
     [...]
    What about nuclear DNA mutation rates?
    >
    >Do we just ignore that much larger amount of information because if we put
    a
    >certain spin on reality, the YEWC framework looks peachy?
     ==========================================================
     =============
     
     and it can be seen that I didn't cut *anything* out! (but see below).

    ==========================
    Taking a quote out of context does not necessarily mean that you removed
    content.
    ==========================
     
    >>HX>the YEWC framework looks peachy?
    >
    >SJ>What is the "YEWC framework"?
     
     [...]
     
    >HX>It is a typo. You see, on my keyboard, the 'w' and the 'e' are next to
    >>each other, and when typing hurriedly one can often hit more than one key
    at a
    >>time. Not doing a spell check allows them to slip through. But I'm glad
    >>you paid such close attention.
     
     SJ>So my "close attention" has foiled Huxter's attempt to found a new school
    >of creationists, the YEWCs! :-)
     
     HX>Curses! I'm found out!
     
     What, no ":-)"?
     
     HX>But here is what I had originally posted:
    >
    >"What about nuclear DNA mutation rates?
    >
    >Do we just ignore that much larger amount of information because if we put
    a
    >certain spin on reality, the YEWC framework looks peachy?"
    >
    >Here is your dissection:
    >
    > HX>because if we put a certain spin on reality,
    >
    > I am glad Huxter said "we"! Claims about putting a "spin on reality"
    cut
    > both ways.
    >
    >
    > HX>the YEWC framework looks peachy?
    >
    > What is the "YEWC framework"?
     
     See also my repost of Huxter's post.
     
    =================================
    Please do. One will see that by inserting a sentence (your response) in the
    middle of my sentence, it changes the intent of the original. It isn't
    really that hard to see.
    =================================

     HX>Clearly, the 'we' I was referring to was not evolutionists,
     
     It seems I misunderstood Huxter. My apologies.
     
     HX>unless you
    >consider that evolutionists would have to put a creationist spin on things
    to
    >see them the creationist way.
     
     No. I was referring to "evolutionists" putting "a certain spin on reality"
    as
     well as creationists.

    =======================================
    One of the dangers of responding line-by-line or point-by-point (I know, I've
    done it too!)
    ========================================
     
     HX>Of course, there is no reason for an
    >evolutionist to put a creationist spin on things.
     
     See above.
     
    >SJ>If it is anything to do with YEC then Huxter is barking up the wrong
    tree
    >>on two counts:
    >
    >>1. I am an *old*-Earth creationist; and
     
     [...]
     
    >HX>Well, pardon me. Either way, it seems that your 'concerns' about the
    >>mtDNA molecular clock are a bit on the weak side.
     
     SJ>What "`concerns'" were those exactly?
     
     HX>Your words:
     
     Which I had already reposted above.
     
     SJ>\"> Here is a New Scientist article, based on a SCIENCE report, which
    says
    >>that molecular clocks, the rate of neutral mtDNA mutation, is possibly 100
    >>times faster than previously thought.
    >>
    >>If this turns out to be really the case, it would bring any "Mitochondrial
    >>Eve", the last common female genetic ancestor, which has been variously
    >>dated from ~ 400-60 kya, into closer contact with Biblical time-frames.
    >>>>"
    >
    >It seems you are presenting the article as support for a biblical
    timeframe.
    >Even if your interpretation were accurate, I fail to see how 400-69 kya is
    >closer to biblical timeframes.
    >==================================
     
     These were not "concerns".

    ==================================
    Sure they were. You did not explicitly state "I have a concern...", but the
    implicit concern is that any information gleaned via molecular clock methods
    is suspect.
    ==================================
     
     And why was Huxter asking me what my "reason" was for posting it?
     
     And why is Huxter claiming they were "on the weak side"?
     
    ====================================
    I retract my 'reason' bit - it is clear what your reason were upon
    re-digesting the whole thing.
    They were on the weak side as I have explained - a single article on a
    single, specific topic was extrapolated by you as an evolution-wide dilemma
    and as support for the OEC position.
    ====================================

    >SJ>2. the issue is the antiquity of *man* not the antiquity of the Earth.
     
     [...]
     
    >HX>Same thing.
     
     SJ>Not really. YECs believe the days of Genesis 1 are literal 24-hour
    periods,
    >so to YECs the "antiquity of the Earth" is effectively the same as the
    >"antiquity of man".
    >
    >But OECs do not believe the days of Genesis 1 are literal 24-hour periods,
    >so to OECs the "antiquity of the Earth" and the "antiquity of man" are two
    >entirely separate issues.
     
     [...]
     
     HX>But it is the same.
     
     I have already explained why it is *not* "the same"!

    ================================
    I don't accept your explanation.
    ===============================
     
     HX>Neither the YEC nor the OEC position seems to be helped
    >by this selective bit of data.
     
     Huxter does not explain why?
     
    ===============================
    I didn't realize that I would need to re-emphasize and reiterate each point.
    Some of the points, mind you, were not explicitly mentioned int he New
    Scientist article. But because an entire concpt does not rest on a single
    article, it is valid to bring up related points. 1) There was no 'mtDNA Eve'
     as such; no single woman from whom out mtDNA all hails. 2) Nuclear DNA
    moleclar clock calculations are at odds with New Scientist mtDNA article.
    In order for the OEC or YEC position to be 'helped' by the NS article,
    certain things would need to be established:
    1) there would have to have been a single woman from whom all humanity
    derived. Population genetics refute this.
    2) it would need to be established that a) the antediluvians existed and b)
    that they could really live for hundreds of years.
    3) that this one study is in fact not in error; that its conclusions can be
    extrapolated to the entire mt genome; that somehow this data supercedes data
    from the nuclear genome
    Thats all I can think of right now. It has been a long day...
    ===============================

     HX>Just out of curiosity, when do OECs believe 'Man' to have been created?
     
     Huxter must already know, if he claims that "Neither the YEC nor the
     OEC position seems to be helped by this selective bit of data"!
     
    ==============================
    I know the YEC date, but my statement was meant to refer to evolution in
    general.
    ==============================

     But to answer Huxter's question, there is AFAIK no consensus among
     OECs when man was created. Hugh Ross believes that 60,000 years ago is
     about the limit of stretching the Biblical genealogies:
     
        "If the Genesis genealogies are anywhere from 10 to 80 percent
        complete, as most conservative scholars suggest, the Adam of Eden
        lived between 7,500 and 60,000 years ago." (Ross H, "Searching
        For Adam", Facts & Faith, Reasons To Believe: Pasadena CA, Vol.
        10, No. 1, First Quarter 1996, p4)
     
        "Given the gaps in some biblical genealogies, the creation of Adam
        and Eve could possibly be dated as far back as 60,000 years ago,
        less reasonably, even earlier." (Ross H, "The Meaning of Art and
        Music", Facts & Faith, Reasons To Believe: Pasadena CA, Vol. 10,
        No. 4, Fourth Quarter 1996, p.6)
     
     I personally do not share Ross' view that the genealogies be stretched too
     far and I do not personally maintain that Adam and Eve were two literal
     people (although I don't rule it out).
     
     The Hebrew word "Adam" literally means "Man" and so I see Adam and
     Eve as probably a symbol for original humankind.

    ==============================
    That sounds reasonable. But 7,500 - 60,000 years is an awfully big
    uncertainty!
    ==============================
     
     The limiting factor to me therefore is the last common ancestor of all
     Homo sapiens, as determined by science, ie. ~ 120 kya. That is why I said:
     
     SJ>I would imagine that Hugh Ross and the ICR will *love* these!
     
     and
     
     SJ>Whatever happens, this shows that scientific `fact', especially in the
     field of human origins, is only as good as the next discovery.
     
     I personally take the position of the Scottish 19th century theologian James
     Orr:
     
        "It is argued that the picture of God working like a potter with wet
        earth, anthropomorphically breathing life into man, constructing
        woman from a rib, with an idyllic garden, trees with theological
        significance, and a talking serpent, is the language of theological
        symbolism and not of literal prose. The theological truth is there,
        and this symbolism is the instrument of inspiration. We are not to
        think in terms of scientific and anti-scientific, but in terms of
        scientific and pre-scientific. The account is then pre-scientific and in
        theological symbolism which is the garment divine inspiration chose
        to reveal these truths for their more ready comprehension by the
        masses of untutored Christians. This is the view of James Orr who
        wrote:
     
        `I do not enter into the question of how we are to interpret the third
        chapter of Genesis-whether as history or allegory or myth, or most
        probably of all, as old tradition clothed in oriental allegorical dress-
        but the truth embodied in that narrative, viz. the fall of man from an
        original state of purity, I take to be vital to the Christian view.' (Orr
        J., The Christian View of God and the World, 1897, p.185)
     
        (Ramm B.L., "The Christian View of Science and Scripture," 1967,
        p.223)
     
     Steve
     
    =======================================
    And you end with something I think we can agree on.



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